THE ITALIAN SOCIETY OF RHEUMATOLOGY CLINICAL PRACTICE GUIDELINES FOR THE MANAGEMENT OF POLYMYALGIA RHEUMATICA





ER stress affects processing of MHC class I-associated peptides

Abstract Background Viral infection and neoplastic transformation trigger endoplasmic reticulum (ER) stress.Thus, a large proportion of the cells that must be recognized by the immune system are stressed cells.Cells respond to ER stress by launching the unfolded protein response (UPR).The UPR regulates the two key processes that control major histo

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